Klaus Reuter Selected Research

queuine tRNA-ribosyltransferase

1/2022	19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
10/2021	Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.
1/2021	Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
1/2020	Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT.
1/2018	Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.
1/2017	Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
1/2013	Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.

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Klaus Reuter Research Topics

Disease

9	Bacillary Dysentery (Shigellosis) 01/2022 - 01/2013
2	Multiple Sclerosis 01/2022 - 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Rupture 01/2021
1	Phenylketonurias (Phenylketonuria) 01/2018
1	Hyperekplexia 03/2002

Drug/Important Bio-Agent (IBA)

7	queuine tRNA-ribosyltransferaseIBA 01/2022 - 01/2013
7	EnzymesIBA 01/2022 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2014
1	LigandsIBA 10/2021
1	DisulfidesIBA 01/2021
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2018
1	Transfer RNA (tRNA)IBA 01/2018
1	Glycine Receptors (Glycine Receptor)IBA 03/2002

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 11/2020 - 10/2014
1	Therapeutics 01/2022